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KMID : 0363320090300020338
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Journal of Korean Oriental Internal Medicine
2009 Volume.30 No. 2 p.338 ~ p.354
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The Effects of Gamijihwang-tang(GJT) on Hyperlipidemia in Rats
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Park So-Ae
Cho Hyun-Kyoung
Yoo Ho-Rhyong
Kim Yoon-Sik
Seol In-Chan
An Joung-Jo
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Abstract
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Objective: Gamijihwang-tang(GJT) has been used as a therapeutic agent for hyperlipidemia in oriental medicine for several years. This study was performed to investigate the effects of GJT on hyperlipidemia in rats using diverse biological methods.
Method: Hyperlipidemia was induced by a hyper-lipidemic diet fed for 4 weeks. Total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, and glucose were measured in the serum after an oral administration of GJT. Lipid peroxidase, SOD, catalase, ACAT, and HMG-CoA were measured in liver after oral administration of GJT.
Result: 1. GJT showed safety against cytotoxicity and toxicity in liver. 2. GJT significantly decreased rat’s body and liver weight. 3. GJT significantly decreased serum total cholesterol and LDL-cholesterol, but increased serum HDL-cholesterol. 4. GJT significantly decreased serum triglyceride and glucose. 5. GJT significantly decreased lipid peroxidation and increased SOD and catalase in liver. 6. GJT significantly decreased ACAT and HMG-CoA reductase of cholesterol manifestation in liver.
Conclusions: These results suggest that GJT might be effective in treatment and prevention of hyperlipidemia.
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KEYWORD
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Gamijihwang-tang(GJT), SHR, Hyperlipidemia, Cholesterol
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